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Original Research Article | OPEN ACCESS

HIPK2 reduces the resistance of gastric cancer cells to cisplatin via p53 pathway

Jiali Mi1, Xing Zhang2 , Yingdong Jia2

1Department of Pharmacy, Suining Central Hospital; 2Department of Gastrointestinal Surgery, Suining Central Hospital, Suining City, Sichuan Province 629000, China.

For correspondence:-  Xing Zhang   Email: zhangxing466@163.com   Tel:+868252267601

Accepted: 24 November 2020        Published: 31 December 2020

Citation: Mi J, Zhang X, Jia Y. HIPK2 reduces the resistance of gastric cancer cells to cisplatin via p53 pathway. Trop J Pharm Res 2020; 19(12):2597-2602 doi: 10.4314/tjpr.v19i12.17

© 2020 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To uncover the functional effect of homologous domain-associated protein kinase 2 (HIPK2) on the viability of cisplatin (DDP)-resistant gastric cancer (GC) cells and elucidate the possible mechanism of action.
Methods: The effect of DDP on GC viability and apoptotic rate was evaluated using MTT and flow cytometry (FCM) assays. The potential effect of HIPK2 on DDP sensitivity and cell apoptosis was investigated in the presence of cisplatin while the effect of HIPK2 on p53 activation was determined by immunoblot assay.
Results: HIPK2 expression was decreased in DDP-resistant GC cell while upregulation of HIPK2 reduced growth, but promoted apoptosis in DDP-resistant GC cells. Further investigations showed that HIPK2 promoted p53 activation, while suppression of p53 weakened the inhibitory effect of HIPK2 on DDP-resistance in GC cells.
Conclusion: The results suggest that HIPK2 is a promising and important therapeutic factor for the regulation of the resistance of GC cells to DDP. Thus, may have a role to play in the management of gastric cancer

Keywords: Gastric cancer, Cisplatin, HIPK2, Homologous domain-associated protein kinase 2, p53 pathway, Therapeutic target

Impact Factor
Thompson Reuters (ISI): 0.6 (2023)
H-5 index (Google Scholar): 49 (2023)

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