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Original Research Article | OPEN ACCESS

Immunomodulatory Activity of the Methanol Extract of Amorphophallus campanulatus (Araceae) Tuber

A S Tripathi1 , V Chitra1, N W Sheikh1, D S Mohale2, A P Dewani2

1SRM College of Pharmacy, Kathankulathur 603 203, Chennai; 2P.W. College of Pharmacy, Yavatmal 445001, Maharashtra, India.

For correspondence:-  A Tripathi   Email: shloksk@rediffmail.com   Tel:+917232237165

Received: 4 July 2009        Accepted: 27 August 2010        Published: 17 October 2010

Citation: Tripathi AS, Chitra V, Sheikh NW, Mohale DS, Dewani AP. Immunomodulatory Activity of the Methanol Extract of Amorphophallus campanulatus (Araceae) Tuber. Trop J Pharm Res 2010; 9(5):451-454 doi: 10.4314/tjpr.v9i5.4

© 2010 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: Traditionally, Amorphophallus campanulatus tuber is used for the treatment of enlarged spleen, rheumatism and tumour. Therefore, this study was designed to evaluate the immunomodulatory activity of the plant material.
Method: The effect of the methanol extract (ME) of Amorphophallus campanulatus tuber on immunological function in mice was studied using charcoal clearance, spleen index and delayed-type hypersensitivity (DTH) response models. The extract was administered orally at doses of 250 and 500 mg/kg.
Results: The extract exhibited immunomodulatory activity by causing a significant decrease in charcoal clearance, spleen index and delayed-type hypersensitivity (DTH) response.
Conclusion: Amorphophallus campanulatus caused decreases in the charcoal clearance rate and cellular immunity by facilitating the footpad thickness response to sheep red blood cell (RBC) in sensitized mice.

Keywords: Amorphophallus campanulatus; immunomodulatory activity, Charcoal clearance, Spleen index, Delayed-type hypersensitivity response

Impact Factor
Thompson Reuters (ISI): 0.6 (2023)
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