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Original Research Article | OPEN ACCESS

Improved Production of Pharmacologically-active Sclerotiorin by Penicillium sclerotiorum

Esther MF Lucas1,2, Yuri Machado1, Alexandre A Ferreira1, Luiza MP Dolabella1, Jacqueline A Takahashi1

1Departamento de Química, ICEx, Universidade Federal de Minas Gerais, Av. Antonio Carlos, 6627, CEP 31270-901, Belo Horizonte, MG; 2Departamento de Química, Universidade Federal de Lavras, Campus Universitário, Centro, CEP 37200-000, Lavras MG, Brazil.

For correspondence:-  Jacqueline Takahashi   Email: jat@qui.ufmg.br   Tel:+553134095754

Received: 1 October 2009        Accepted: 8 May 2010        Published: 25 August 2010

Citation: Lucas EM, Machado Y, Ferreira AA, Dolabella LM, Takahashi JA. Improved Production of Pharmacologically-active Sclerotiorin by Penicillium sclerotiorum. Trop J Pharm Res 2010; 9(4):365-371 doi: 10.4314/tjpr.v9i4.6

© 2010 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: The aim of this work was to study the optimum conditions for the production of sclerotiorin, a highly active secondary metabolite of Penicillium sclerotiorum under different cultural media.
Methods: A Brazilian strain of P. sclerotiorum was grown under different culture conditions in two liquid media (malt and a dextrose-peptone salt medium supplemented with sodium chloride) and in solid state fermentation in rice. Sclerotiorin production was monitored by high performance liquid chromatography (HPLC).
Results: Quantitative analysis of sclerotiorin content by HPLC indicated that sclerotiorin production reached the highest level (up to 313 + 10 mg.L-1) in the dextrose-based medium after 10 days of fermentation. Rice and malt broth showed lower production levels.
Conclusion: Enhanced production of P. sclerotiorin for pharmaceutical development can be achieved using dextrose-based cultures.

Keywords: Penicillium sclerotiorum, Sclerotiorin,Yield improvement, HPLC, Pharmaceutical industry

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