T A Abere1 
,
A O Onyekweli2,
G C Ukoh3
For correspondence:- T Abere Email: eseabere@yahoo.com
Published: 23 March 2007
Citation: Abere TA, Onyekweli AO, Ukoh GC. In vitro Antimicrobial Activity of the Extract of Mitracarpus scaber Leaves Formulated as Syrup. Trop J Pharm Res 2007; 6(1):679-682 doi: 10.4314/tjpr.v6i1.7
© 2007 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To formulate the crude extract of the leaves of Mitracarpus scarber “Zucc” as a syrup.
Method: The antimicrobial activity of the formulation was assessed using agar plates and concentrations of the extract varying between 25mg/ml and 300mg/ml to determine the minimum inhibitory concentration at 37oC against bacterial and fungal organisms namely, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Sarcina lutea, Candida albicans and Klebsiella pneumoniae.
Result: The growth of Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae and Candida albicans was inhibited by the formulation at a minimum inhibitory concentration of 75mg/ml. Pseudomonas aeruginosa, and Sarcina lutea resisted all the concentrations of the formulation used. The presence of sucrose in the formulation rendered the formulation pleasant to taste.
Conclusion: The extract from the leaves of Mitracarpus scarber “Zucc” can be formulated into a pleasantly tasting oral dosage form despite its bitter taste.
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