Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

In-vitro evaluation of dexpanthenol-loaded nanofiber mats for wound healing

Sakine Tuncay Tanrıverdi¹ , Bilge Suat¹, Erkan Azizoglu¹, Fadime Aydın Köse², Özgen Özer¹

¹Ege University, Faculty of Pharmacy, Department of Pharmaceutical Technology; ²Ege University, Faculty of Pharmacy, Department of Biochemistry, 35100, Izmir, Turkey.

For correspondence:- Sakine Tanrıverdi Email: sakinetuncay@windowslive.com Tel:+902323111368

Accepted: 26 February 2018 Published: 31 March 2018

Citation: Tanrıverdi ST, Suat B, Azizoglu E, Köse FA, Özer &. In-vitro evaluation of dexpanthenol-loaded nanofiber mats for wound healing. Trop J Pharm Res 2018; 17(3):387-394 doi: 10.4314/tjpr.v17i3.1

© 2018 The authors.
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Abstract

Purpose: To prepare a novel dexpanthenol (DEX)-loaded nanofiber mats for wound healing.

Methods: A novel bioactive wound dressing formulation with dexpanthenol was developed by electrospinning method. Poly (lactic-co-glycolic acid), poly (ethylene oxide) and poly (caprolactone) were used as polymers. Morphological features, swelling properties, in-vitro release behavior, and cell viability properties of the formulations were evaluated.

Results: Morphological examination of mats confirmed successful formation of the fibers. Swelling of nanofiber mats results was 34.44 ± 1.05, 18.59 ± 2.11, 86.06 ± 3.25 and 44.62 ± 1.75 % for polycaprolactone (PCL), PCL + DEX, poly lactic-co-glycolic acid (PLGA) and PLGA + DEX, respectively, and occurred in a controlled manner. PLGA + DEX formulation has advantage over PCL + DEX and poly (ethylene oxide) (PEO) + DEX due to controlled in-vitro release of DEX. The highest cell viability was afforded by PLGA+DEX formulation.

Conclusion: DEX-loaded PLGA nanofiber formulation may be useful as an alternative wound dressing due its suitable mechanical and biological properties

Keywords: Dexpanthenol, Electrospinning, Wound dressing, Polycaprolactone, Poly lactic-co-glycolic acid, Poly (ethylene oxide)