Abeer S Alghamdi, Hussah M Alobaid, Ahmed M Rady, Badr Abdullah Aldahmash Wejdan S AL-Qahtani, Aisha H Alqarni, Samiah A Almalki, Doaa M Elnagar

For correspondence:-  Doaa Elnagar   Email: elnagard1@yahoo.com   Tel:+966-554425428

Received: 3 September 2024        Accepted: 9 December 2024        Published: 28 December 2024

Citation: Alghamdi AS, Alobaid HM, Rady AM, S AL-Qahtani BA, Alqarni AH, Almalki SA, et al. Inhibitory effect of PD173074 drug on DMBA-induced mammary carcinoma in female Swiss albino mice. Trop J Pharm Res 2024; 23(12):1983-1989 doi: 10.4314/tjpr.v23i12.3

© 2024 The authors.
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Abstract

Purpose: To determine the effect of PD173074 on mammary carcinoma. Methods: Virgin female mice were randomly divided into 4 groups of 10 mice per group. Group 1 (control) received clean water, group 2 received an oral dose of 50 mg/kg PD173074 twice a week, group 3 received a single dose of 50 mg/kg 7,12-Dimethylbenz(a)anthracene (DMBA) in the breast for carcinoma induction, group 4 received DMBA and after that treated with PD173074 one week later for 4 weeks. Hormonal analysis, oxidative stress, levels of cytokines IL6 and TNF-α, and histopathological and immunohistochemical analysis were carried out. Results: Treatment with PD173074 significantly lowered estrogen, progesterone, oxidative stress indices, cytokines IL6, and TNF-α levels (p < 0.05) raised due to carcinoma induction. Pyrido (2,3-d) pyrimidine derivative PD173074 lowered the Nottingham histopathological score and reduced the incidence of invasive ductal carcinoma. Furthermore, immunohistochemical analysis showed that post-treatment with PD173074 significantly decreased K167 expression (p < 0.05). Conclusion: PD173074 significantly reduces estrogen, progesterone, oxidative stress indices, cytokines, TNF-α, Nottingham histopathological score, and KI-67 expression. Additional studies would be required to validate the actual mechanisms of this drug action.