Tropical Journal of Pharmaceutical Research

Review Article | OPEN ACCESS

Injectable In Situ Forming Microparticles: A Novel Drug Delivery System

Evren Algın Yapar¹ , Özge İnal², Yalçın Özkan³, Tamer Baykara⁴

¹Ministry of Health of Turkey, General Directorate of Pharmaceuticals and Pharmacy, SÃ¶ğÃ¼tÃ¶zÃ¼ Mah. 2176. Sok. No:5 Kat:6, 06520 Ã‡ankaya-Ankara; ²Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Ankara, 06100 Tandoğan-Ankara; ³Department of Pharmaceutical Technology, GÃ¼lhane Military Medical Academy, 06018 Etlik-Ankara; ⁴UNAM (Institute of Materials Science and Nanotechnology), Bilkent University, 06800 Bilkent-Ankara, Turkey.

For correspondence:- Evren Yapar Email: algin@pharmacy.ankara.edu.tr Tel:+905323825686

Received: 5 August 2011 Accepted: 20 February 2012 Published: 24 April 2012

Citation: Yapar EA, İnal &, Özkan Y, Baykara T. Injectable In Situ Forming Microparticles: A Novel Drug Delivery System. Trop J Pharm Res 2012; 11(2):307-318 doi: 10.4314/tjpr.v11i2.19

© 2012 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Pharmaceutical formulation research has recently been focusing on delivery systems which provide long therapeutic effects and reduced side effects, and involving simplified production stages and facilitated application process. In situ forming microparticle (ISM) systems, one of the latest approach in this field, offer a new encapsulation technique and meet the objectives stated above. Factors such as the carrier used to form the multiparticles, amount and type of drug and the vehicle type can be taken as the main performance criteria for these systems. Ongoing studies have shown that this new multiparticulate drug delivery system is suitable for achieving new implant delivery system with low risk of dose-dumping, capable of being modulated to exhibit varying release patterns, reproducible, easily applicable and well-tolerated compared with classically surgical implants.

Keywords: Injectable, In situ forming, Microparticle system, Controlled drug delivery