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Original Research Article | OPEN ACCESS

Investigation into the prophylactic and therapeutic activity of coenzyme Q10 against COVID-19

Ali AL-Samydai1 , Maha N Abu Hajleh2, Amal Akour3,4, Naeem Shalan1, Nisrein Jaber4, Lidia Kamal Al-Halaseh5, Muhammed Alzweiri6

1Pharmacological and Diagnostic Research Centre, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman 19328, Jordan; 2Department of Cosmetic Science, Pharmacological and Diagnostic Research Centre, Faculty of Allied Medical Sciences, Al-Ahliyya Amman University, Amman 19328, Jordan; 3Department of Biopharmaceutics and Clinical Pharmacy, School of Pharmacy, University of Jordan, Amman 19328, Jordan; 4Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman 11733, Jordan; 5Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mutah University, Al-Karak 61710, Jordan; 6Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Jordan, Amman 19328, Jordan.

For correspondence:-  Ali AL-Samydai   Email: a.alsamydai@ammanu.edu.jo

Accepted: 23 October 2021        Published: 30 November 2021

Citation: AL-Samydai A, Hajleh MN, Akour A, Shalan N, Jaber N, Al-Halaseh LK, et al. Investigation into the prophylactic and therapeutic activity of coenzyme Q10 against COVID-19. Trop J Pharm Res 2021; 20(11):2387-2393 doi: 10.4314/tjpr.v20i11.22

© 2021 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To evaluate the anti-SARS CoV-2 effect of Coenzyme Q 10, Ubiquinol-10, and idebenone, which have beneficial therapeutic applications against diverse virus types, using molecular docking approach.
Methods: The potential activity of Coenzyme Q10, Ubiquinol-10, and Idebenone against viral infections was explored through the collection of data from relevant literature, and by modelling these compounds virtually, using in silico investigation methods.  
Results: Coenzyme Q10 and ubiquinol-10 showed significant docking performance. They interacted with numerous amino acid residues of the main protease of SARS-CoV-2 ACE2 (7C8J), Alpha thrombin (1AE8), TYRO (4TS1) protein targets sides, SARS-coronavirus Orf7a accessory protein (1XAK), TNF (1RJ8), and Cytokine/receptor (1I1R).
Conclusion: The findings of our study showed promising inhibitory activities of the selected compounds against the main proteases of SARS-CoV-2. Consequently, these compounds have theoretical effects on inhibiting the viral entry, reproduction, and ultimately the prevention and/or treatment of the SARS-CoV2 infection.

Keywords: SARS-CoV-2, Docking, Coenzyme Q10, Ubiquinol-10, Idebenone

Impact Factor
Thompson Reuters (ISI): 0.6 (2023)
H-5 index (Google Scholar): 49 (2023)

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