Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Investigation of hemorheological and analgesic properties of Qing-Nao tablets

Guo-qi Xie¹, Feng Su², Chang-sheng Guo³ , Xu-hui Zhang⁴, Shao-jun Hao⁵, Dan-dong Li⁶, Zheng-chen Zhang⁵

¹Cardiology Department of Cardiology, The 371st Central Hospital of People's Liberation Army; ²Department of Neurosurgery, The 152st Central Hospital of People's Liberation Army; ³Department of Orthopedics; ⁴Drug and Equipment Section; ⁵Department of Neurosurgery, The 371st Central Hospital of People's Liberation Army, Xinxiang, Henan, 453000, China.

For correspondence:- Chang-sheng Guo Email: gcsjfj@163.com

Received: 28 December 2016 Accepted: 18 May 2017 Published: 29 June 2017

Citation: Xie G, Su F, Guo C, Zhang X, Hao S, Li D, et al. Investigation of hemorheological and analgesic properties of Qing-Nao tablets. Trop J Pharm Res 2017; 16(6):1369-1376 doi: 10.4314/tjpr.v16i6.22

© 2017 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To investigate the hemorheological and analgesic potentials of Qing-Nao tablet (QNT).

Methods: Sixty animals were divided into 6 groups (n = 10 for each group): normal, control, positive and 3 QNT-treated groups (QNT-H, QNT-M, QNT-L). Animals in normal and control groups received normal saline orally, while those in positive and QNT groups were orally administered either a suspension of the contents of Nao-luo-tong capsules or QNT. Hemorheological indices, including blood viscosity, plasma viscosity, activated partial thromboplastin time (APTT), thrombin time (TT), prothrombin time (PT) and fibrinogen (FIB), were determined. Acetic acid-induced writhing, tail tenderness and hot plate tests, as well as tests on microcirculation and balance/coordination were also carried out.

Results: Acute toxicity results showed that QNT is a safe drug. Whole blood and plasma viscosities of the 3 QNT-treated groups significantly decreased (p < 0.05). However, TT levels of the 3 QNT-treated animals significantly increased (p < 0.05), whereas APTT and FIB values decreased significantly (p < 0.01). Moreover, QNT significantly increased analgesia in three animal models (p < 0.05). QNT-H also significantly improved balance and coordination abilities of mice (p < 0.05).

Conclusion: These results demonstrate that QNT improves microcirculation and analgesia, and may be a source of promising candidate drugs for the treatment of brain concussion sequelae.

Keywords: Qing-Nao tablet, Hemorheological, Analgesic effects, Brain concussion sequelae, Microcirculation, Balance and coordination abilities