Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Isolation and Characterization of Batatasin III and 3,4'-Dihydroxy-5-methoxybibenzyl: A Pair of Positional Isomers from Sunipia scariosa

J Z Yang¹, J H Jiang¹, W J Wang^1,2, Y M Zhang^1,3, Y Liu¹, Y G Chen¹

¹Department of Chemistry, Yunnan Normal University, Kunming 650500; ²Department of Traditional Medicine, Yunnan University of Traditional Chinese Medicine; ³Department of Environmental and Municipal Engineering, Kunming Metallurgy School, Kunming, China.

For correspondence:- Y Chen Email: ygchen48@gmail.com Tel:+8687165941089

Received: 5 May 2013 Accepted: 28 February 2014 Published: 23 April 2014

Citation: Yang JZ, Jiang JH, Wang WJ, Zhang YM, Liu Y, Chen YG. Isolation and Characterization of Batatasin III and 3,4'-Dihydroxy-5-methoxybibenzyl: A Pair of Positional Isomers from Sunipia scariosa. Trop J Pharm Res 2014; 13(4):533-535 doi: 10.4314/tjpr.v13i4.7

© 2014 The authors.
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Abstract

Purpose: To isolate and characterize chemical compounds of biological importance from the whole plant of Sunipia scariosa.

Methods: The whole plant of Sunipia scariosa was extracted with methanol (MeOH) and chromatographed on silica gel and sephadex LH-20 to afford the pure isolates. High perfomance liquild chromatography (HPLC) was used for further purification of the isolated compounds. Characterization of the isolated compounds was achieved by 1H and 13C nuclear magnetic resonance spectroscopy (NMR) and mass spectrometry (MS).

Results: Batatasin III (3,3’-dihydroxy-5-methoxybibenzyl) and 3,4’-dihydroxy-5-methoxybibenzyl, a pair of positional isomers, were isolated from the whole plant of Sunipia scariosa. The yields of the two isomers were 60 and 40 %, respectively, from the mixture of two compounds.

Conclusion: Batatasin III and 3,4’-dihydroxy-5-methoxybibenzyl, a pair of positional isomers were successfully isolated from the whole plant of Sunipia scariosa for the first time.

Keywords: Sunipia scariosa, Batatasin III, 3,4'-Dihydroxy-5-methoxybibenzyl, Isomers