Huan-wei Zhuang1,
Hong-du Fu1,2,5,
Shutang Bai1,
Li-ming Liang1,
Hua Ou-Yang1,
Liang Zhang2 
For correspondence:- Liang Zhang Email: uug68952@126.com Tel:+8617798461376
Accepted: 2 May 2020 Published: 30 November 2020
Citation: Zhuang H, Fu H, Bai S, Liang L, Ou-Yang H, Zhang L. Long intergenic non-protein coding RNA 00174 promotes cardiac hypertrophy by targeting miR-150-5p. Trop J Pharm Res 2020; 19(11):2349-2355 doi: 10.4314/tjpr.v19i11.15
© 2020 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: miR-150-5p is associated with several diseases but its relation with cardiac hypertrophy (CH) is yet to be unveiled. However, long intergenic non-protein coding RNA 174 (LINC00174) is implicated in CH. The purpose of this study was to investigate the roles of LINC00174 and miR-150-5p in relation to CH progression.
Methods: A mechanical cyclic stretch was applied to create 4 groups of H9 cardiomyocytes: 15 % 7, 15, 24 and 48 hr stretches, as well as unstretched control. Transfection method was used to up-regulate ex
Results: ex
Conclusion: LINC00174 and miR-150-5p may be novel biomarkers for early diagnosis of CH.
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