Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Management of diabetes and arthritis â€“A systematic review

Syed Wasif Gillani¹ , Mohi Iqbal Mohammed Abdul^1,2, Hisham A Zaghloul¹, Irfan Altaf Ansari³, Syed Ata-ur-Rahman¹, Sadaf Farooqui¹

¹College of Pharmacy, Taibah University, Al-Madinah Munawarah, Saudi Arabia; ²College of Pharmacy, University of Philippines, Manila, Philippines; ³College of Medicine, Taibah University, Al-Madinah Munawarah, Saudi Arabia.

For correspondence:- Syed Gillani Email: wasifgillani@gmail.com

Accepted: 19 April 2018 Published: 28 May 2018

Citation: Gillani SW, Abdul MI, Zaghloul HA, Ansari IA, Ata-ur-Rahman S, Farooqui S. Management of diabetes and arthritis â€“A systematic review. Trop J Pharm Res 2018; 17(5):967-973 doi: 10.4314/tjpr.v17i5.29

© 2018 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: Diabetes is a metabolic syndrome with reported musculoskeletal effects. This systemic review aimed to identify a relationship between diabetes and arthritis; disease-related risk factors, the effect of diet in disease management and the effect of anti-arthritic drugs on diabetes treatment.

Methods: This study analysed 20 articles identified and selected according to the study criteria. PRISMA guidelines were used for identification and screening of literature. Data search covered several primary databases, including Pubmed, Wiley library, Scopus, Clinical Trial Registry, etc.

Results: The study findings suggest a significant correlation between diabetes and arthritis. Obesity, impaired glucose tolerance (MS components), vascular cell adhesion molecule 1 (VCAM-1) hypertension and dyslipidemia are the most common risk factors leading to disease progression. Omega -3-fatty acid showed no protective effect on disease condition.

Conclusion: The findings indicate that anti-tumor necrosis factor (Tnf)-α, disease modifying anti-rheumatic drugs, and Interleukin receptors antagonist improved the efficacy of diabetic medication and maintained blood sugar levels. However, Tnf-α reduced glucose intolerance, and therefore, its therapeutic use in conjunction with diabetic medications should be limited.

Keywords: Diabetes, Arthritis, Risk factors, Diet, Pathogenesis, Disease progression, Medication