Bogdana B Galabova 
For correspondence:- Email: bbgalabova@gmail.com Tel:+359889665844
Accepted: 26 April 2021 Published: 31 May 2021
Citation: Galabova BB. Mesoporous silica nanoparticles: Synthesis, functionalization, drug loading and release - A review. Trop J Pharm Res 2021; 20(5):1091-1100 doi: 10.4314/tjpr.v20i5.30
© 2021 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
A brief survey on the synthesis of several types of mesoporous silica nanoparticles and their uses as drug delivery nanocarriers is presented in this study. Mesoporous silica nanoparticles (MSNs) have a small pore size, resulting in a large surface area and porosity. These characteristics are easily adjustable, conferring on MSNs advantages over other nanoparticles for use in medicine and pharmacy. Previous and latest trends in the technology of this type of nanoparticles, and the possibilities for their application in drug loading are considered, as well as methods for increasing drug loading capacity, functionalization and release of bioactive substances. It has been found that the method used for the synthesis of some types of MSNs results in better drug loading. The functionalization of nanoparticles not only allows for more successful loading of bioactive substances in its pores, it also successfully controls drug release. Moreover, these versatile nanoparticles enhance the solubility of poorly-soluble drugs, thereby overcoming one of the biggest problems in the absorption of these drugs.
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