Tropical Journal of Pharmaceutical Research

Review Article | OPEN ACCESS

Orally Disintegrating Tablets: A Review

Jaysukh J Hirani¹ , Dhaval A Rathod¹, Kantilal R Vadalia²

¹Smt. R.D.Gardi B. Pharmacy College, Rajkot-360110; ²Shri H.N.Shukla College of Pharmacy, Rajkot, Gujarat, India.

For correspondence:- Jaysukh Hirani Email: jay2150@yahoo.com Tel:+ 919925062150

Received: 30 June 2008 Accepted: 02 November 2008 Published: 17 April 2009

Citation: Hirani JJ, Rathod DA, Vadalia KR. Orally Disintegrating Tablets: A Review. Trop J Pharm Res 2009; 8(2):161-172 doi: 10.4314/tjpr.v8i2.10

© 2009 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Drug delivery systems are becoming increasingly sophisticated as pharmaceutical scientists acquire a better understanding of the physicochemical and biochemical parameters pertinent to their performance. Over the past three decades, orally disintegrating tablets (ODTs) have gained considerable attention as a preferred alternative to conventional tablets and capsules due to better patient compliance. ODTs are solid dosage forms containing medicinal substances which disintegrate rapidly, usually in a matter of seconds, when placed on the tongue. Products of ODT technologies entered the market in the 1980s, have grown steadily in demand, and their product pipelines are rapidly expanding. New ODT technologies address many pharmaceutical and patient needs, ranging from enhanced life-cycle management to convenient dosing for paediatric, geriatric, and psychiatric patients with dysphagia. This has encouraged both academia and industry to generate new orally disintegrating formulations and technological approaches in this field. The aim of this article is to review the development of ODTs, challenges in formulation, new ODT technologies and evaluation methodologies, suitability of drug candidates, and future prospects.

Keywords: Orally disintegrating tablet, Improved bioavailability, Texture analyser, NanomeltTM