Fu-Liang Wang1,
Hong-Mei Ji2,
Jian-You Zha3,
Gui-Jun Xu4,
Yu-Zhong Guan5,
Ye-Jun Chen1 
For correspondence:- Ye-Jun Chen Email: chenyejun335@gmail.com Tel:+865337181956
Received: 5 January 2015 Accepted: 3 July 2015 Published: 30 August 2015
Citation: Wang F, Ji H, Zha J, Xu G, Guan Y, Chen Y. Penetration enhancement effect of turpentine oil on transdermal film of ketorolac. Trop J Pharm Res 2015; 14(8):1341-1348 doi: 10.4314/tjpr.v14i8.4
© 2015 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To prepare transdermal films of ketorolac tromethamine (KT) and study the effect of turpentine oil as a penetration enhancer for the drug.
Methods: Transdermal films of KT were prepared with Carbopol-934 and ethyl cellulose, with turpentine oil as the penetration enhancer, using solvent evaporation method. The films were characterized for physicochemical properties, ex vivo permeation, as well as in vivo anti-inflammatory and analgesic activities in Wistar rats.
Results: The transdermal films were uniform in weight and thickness, flat, with high drug content (93.9 to 98.5 %) and of high folding endurance (134.0 to 180.0). Drug permeation through excised rat abdominal skin was prolonged, with the total drug release ranging from 58.88 to 88.98 % in 24 h. The films containing penetration enhancer showed higher drug permeation than the one without the enhancer; furthermore, drug permeation increased with increase in the concentration of the enhancer. The films were non-irritant to the skin. The transdermal films prepared with permeation enhancers showed greater anti-inflammatory activity (87.55 ± 2.50 and 83.24 ± 2.29 % inhibition of rat paw edema at the end of 12 h for formulations F2 and F3, respectively, compared to that of the formulation without enhancer with 69.99 %) as well as greater analgesic activity (quicker onset of analgesia in 1.5 h with longer duration of 10 to 12 h).
Conclusion: Transdermal films of ketorolac have a potential for use in the treatment of pain and inflammation. Incorporation of turpentine oil in the films enhances not only drug flux but also analgesic and anti-inflammatory activities in rats.
Archives
News Updates
Fulltext in PDF