A Azmat1 
,
M Ahmed2
For correspondence:- Azmat Email: aishaazmatkhan@hotmail.com Tel:+00966025270000
Received: 18 October 2013 Accepted: 9 September 2014 Published: 24 November 2014
Citation: Azmat A, Ahmed M. Pharmacological Evidence of Hypotensive Activity of Somina (Herbal drug) in Normotensive Rats. Trop J Pharm Res 2014; 13(11):1863-1866 doi: 10.4314/tjpr.v13i11.13
© 2014 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To evaluate the effects of somina (herbal drug) on the arterial blood pressure.
Methods: Hypotensive activity was studied in pentothal sodium-anesthetized normotensive albino rats at various doses of somina (5, 10, 15, 20 and 35 mg/kg). The drugs were administered intravenously and changes in arterial blood pressure (systolic, diastolic and mean arterial blood pressure) were registered directly from the carotid artery. Acetylcholine (Ach, 10-4 M) was used as positive control for comparison while the receptor activity of Ach and somina was assessed using atropine (muscarinic receptor antagonist) on rat heart.
Results: Somina caused dose-dependent significant (p < 0.05) reduction in mean arterial pressure blood pressure (MABP). The 35 mg/kg dose caused 46.7 % fall in MABP, which was significant (p < 0.05) when compared with control. The results were comparable with those of acetylcholine (10-4 M) which showed 45.6 % fall in MABP. For receptor activity, atropine (10-4 M) was administered i.v., and then the Ach and somina (45 mg/kg) was administered one at a time. Non-significant fall in MABP was observed (1.2 and 20 %, p > 0.05) in rats that were pretreated with atropine.
Conclusion: Somina possesses potent hypotensive effect at different doses in normal rats by stimulating non-selective muscarinic receptors.
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