Juriyati Jalil , Muhammad Afiq, Syahira Wahab, Khairana Husain

For correspondence:-  Juriyati Jalil   Email: juriyatijalil@ukm.edu.my

Received: 11 June 2024        Accepted: 12 March 2025        Published: 30 March 2025

Citation: Jalil J, Afiq M, Wahab S, Husain K. Phytoconstituents and pharmacological activities of Mitrephora species (Annonaceae): a review. Trop J Pharm Res 2025; 24(3):411-427 doi: 10.4314/tjpr.v24i3.14

© 2025 The authors.
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Abstract

This study reviewed the phytoconstituents and pharmacological properties of 13 Mitrephora species, namely, Mitrephora alba Ridl., Mitrephora celebica Scheff., Mitrephora diversifolia (Span.) Miq., Mitrephora glabra Scheff., Mitrephora heyneana (Hook. f. and Thomson) Thwaites, Mitrephora maingayi Hook. f. and Thomson, Mitrephora sirikitiae Weeras., Chalermglin and RMK Saunders, Mitrephora teysmannii Scheff., Mitrephora thorelii Pierre, Mitrephora tomentosa Hook.f. and Thomson, Mitrephora vulpina CEC. Fisch., Mitrephora wangii Hu, and Mitrephora winitii Craib. The data retrieved from key databases revealed the presence of 85 phytoconstituents derived from the genus Mitrephora, and were categorized based on their chemical composition (alkaloids, terpenoids, polyacetylene acids, lignans, and lignanamides). This review highlights the promising uses of these phytoconstituents in cancer therapeutics, microbial infections, malaria, and inflammation, and in modulating platelet activity.