Naglaa Gamil Shehab1,2 
,
Rawoof Khan Gafoor Khan3,
Eiman Shams Eldin Elgailani4,
Kholoud Yousuf Abu Shawish2
For correspondence:- Naglaa Shehab Email: naglaa@dpc.edu Tel:+71503212716
Accepted: 22 September 2018 Published: 31 October 2018
Citation: Shehab NG, Khan RK, Elgailani ES, Shawish KY. Possible intrusive food interaction with oral dabigatran’s anticoagulant activity in a rat models. Trop J Pharm Res 2018; 17(10):2031-2036 doi: 10.4314/tjpr.v17i10.20
© 2018 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To evaluate the synergistic or antagonistic interaction between oral dabigitran etexilate (Pradaxa) and some foods.
Methods: Aqueous extracts of sweet orange, cabbage, ginger, green tea, garlic and pineapple were prepared and lyophilized, and total phenolic acids and flavonoid contents evaluated. The residues of the aqueous extracts were given daily to the rats (500 mg/kg dose, oral) 1 h after administration of dabigatran (1.83 mg/kg dose) for 14 days. Bleeding time, International Normalized Ratio (INR), prothrombin time (PT) as well as alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) in blood were measured.
Results: Oral administration of Pradaxa with all the test food (except cabbage) significantly increased bleeding time, INR and PT. Pradaxa interaction with cabbage significantly decreased bleeding tendencies but the drug did not produce any major elevation of liver enzyme levels (ALT, AST and ALP). Conversely, significant elevation in ALP level was observed only after aqueous extract of ginger was administered with Pradaxa. Green tea and garlic significantly increased ALT and AST levels.
Conclusion: Synergistic interaction occurrs between dabigatran etexilate with the selected foods, but interaction with cabbage antagonistic
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