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Original Research Article | OPEN ACCESS

Post-chemotherapy miR-146a expression and its prognostic potential in oral cancer patients

Yuanyuan Sun1, Leilei Li2, Wensong Hao3

1Urumqi Stomatological Hospital, Urumqi 830000; 2Department of Dental, People's Hospital of Dongying, Dongying 257091; 3Medical College of Liaocheng University, Shandong 252000, China.

For correspondence:-  Wensong Hao   Email: rmqj66@163.com

Accepted: 17 September 2021        Published: 31 October 2021

Citation: Sun Y, Li L, Hao W. Post-chemotherapy miR-146a expression and its prognostic potential in oral cancer patients. Trop J Pharm Res 2021; 20(10):2205-2211 doi: 10.4314/tjpr.v20i10.27

© 2021 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To determine miR-146a expression level after chemotherapy in oral cancer patients, and its prognostic value.
Methods: Quantitative reverse transcription polymerase chain reaction (qRT-PCR) was used for the determination of miR-146 expression levels. Based on the results, the analysis of the miR-146a expression in oral cancer patients was performed by drawing ROC curve to provide information on the prognostic value of miR-146a. The survival of the patients was monitored over a period of 5 years. The patients were categorized into high- and low-expression groups, and multivariate Cox regression analysis method was adopted to provide a more comprehensive analysis of individual risk factors influencing the prognosis of oral cancer.
Results: The miR-146a expression level in patients after chemotherapy was lower than that in patients before they received chemotherapy (p < 0.05). The specificity of using miR-146a to predict oral cancer was 76.83 %, the sensitivity 69.44 %, and the area between the curve and x-axis 0.78. In contrast, the survival level was significantly greater in high-expression patients (p < 0.05).
Conclusion: The independent risk parameters for buccal carcinoma are drinking, smoking, chronic leukoplakia, and miR-146a.

Keywords: Oral carcinoma, MiR-146a, Clinical effectiveness, Prognostic potential

Impact Factor
Thompson Reuters (ISI): 0.6 (2023)
H-5 index (Google Scholar): 49 (2023)

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