Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Preparation, characterization and stability of silver sulfadiazine nanoliposomes

Delia Alkhatib¹, Noha Zelai²

¹Department of Biochemistry; ²Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.

For correspondence:- Noha Zelai Email: nzelai@kau.edu.sa Tel:+966509357153

Accepted: 23 March 2021 Published: 30 April 2021

Citation: Alkhatib D, Zelai N. Preparation, characterization and stability of silver sulfadiazine nanoliposomes. Trop J Pharm Res 2021; 20(4):665-671 doi: 10.4314/tjpr.v20i4.1

© 2021 The authors.
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Abstract

Purpose: To prepare, characterize and investigate the stability and drug release profile of silver sulfadiazine (AgSD) nanoliposomes as functions of pH, UV exposure, and/or heat.

Methods: Silver sulfadiazine (AgSD) nanoliposomes were prepared. The stability and release properties of the free drug and nanoliposomal formulations of AgSD as functions of pH, UV exposure, and/or heat were analyzed. The analyses were performed at different time points.

Results: The results of characterization showed that acidic, basic and neutral silver sulfadiazine nano-liposomal suspensions (AgSD NLSs) were produced as stable homogenous formulations, as indicated by low polydispersity index (PDI) and high zeta potential. The three AgSD NLSs and AgSD were unstable under different heat and/or UV conditions. The pH tended to shift towards neutrality, starting from day 1. Silver sulfadiazine nanoliposomal suspensions (AgSD NLSs) and free drug (AgSD) exhibited similar release properties (100 % of the drug was released at day 12).

Conclusion: Incorporation of AgSD into nanoliposomes has no significant effect on the stability and in vitro release properties of the drug. This indicates that NLS did not change the physical characteristics of the drug. Studies that focus only on improving the lipophilicity of silver sulfadiazine may benefit from these results.

Keywords: Malaria, Nanoliposomes, Drug release, Silver sulfadiazine, Suspension