D V Gowda,
KSY Hemant 
,
Afrasim Moin,
H G ShivaKumar
For correspondence:- KSY Hemant Email: haisunny2@yahoo.co.in
Received: 5 March 2011 Accepted: 11 February 2012 Published: 24 April 2012
Citation: Gowda DV, Hemant K, Moin A, ShivaKumar HG. Preparation and Characterization of Sugar Cane Wax Microspheres Containing Indomethacin. Trop J Pharm Res 2012; 11(2):177-183 doi: 10.4314/tjpr.v11i2.2
© 2012 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To formulate and characterize indomethacin (IM) microspheres prepared with sugar cane wax microsperes.
Methods: Microspheres were prepared by melt-emulsified dispersion and cooling-induced solidification method. The microspheres were characterized by scanning electron microscopy (SEM) and differntial scanning calorimetry (DSC) as well as for drug loading, and in vitro and in vivo release in albino sheeps.
Results: SEM images showed that the microspheres were spherical in shape and more than 98.0 % of the isolated microspheres were in the size range 345 - 360 μm. The Cmax, Tmax, AUCO - 24 and T1/2 values were 2123 ± 30 ng/ml, 3.1 h, 9734 ± 126 ng/ml h−1, and 2.68 ± 0.03 h−1 for the reference product, Microcid® SR, and 1989 ± 26 ng/ml, 3.0 h, 8013 ± 79 ng/ml h−1, and 2.79 ± 0.12 h−1, respectively, for the test formulation.
Conclusion: Based on this study, it can be concluded that the developed indomethacin-loaded wax microsheres and Microcid® SR capsule are bioequivalent in terms of rate and extent of absorption.
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