Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Preparation and physicochemical evaluation of transdermal aerosols containing ketoprofen

Fahimeh Ahmadi, Alireza Vatanara , Esmaeil Moazeni, Fatemeh Hoseini, Majid Darabi

Aerosol Research Laboratory, Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran;

For correspondence:- Alireza Vatanara Email: vatanara@sina.tums.ac.ir Tel:+982166980445

Received: 16 November 2016 Accepted: 11 July 2017 Published: 31 August 2017

Citation: Ahmadi F, Vatanara A, Moazeni E, Hoseini F, Darabi M. Preparation and physicochemical evaluation of transdermal aerosols containing ketoprofen. Trop J Pharm Res 2017; 16(8):1813-1818 doi: 10.4314/tjpr.v16i8.9

© 2017 The authors.
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Abstract

Purpose: To prepare transdermal ketoprofen metered-dose aerosol formulations containing menthol and isopropyl myristate (IPM) as penetration enhancers and to evaluate their physicochemical and permeation properties.

Methods: Selected ratios of ketoprofen, ethanol, polyvinylpyrrolidone K30 (PVP K30, anti-nucleant), and penetration enhancers were mixed and filled into aluminum aerosol cans with hydrofluoroalkane-134a as propellant. The physicochemical properties of the films, and their ex vivo permeation properties in rat skin were investigated over a 24-h period. Rat skin was exposed to a definite dose of each ketoprofen film to determine the quantity of drug in the receptor compartment over a 24-h period.

Results: All the transdermal formulations showed good integrity and film uniformity. Formulations with permeation enhancers presented higher rates of skin penetration compared to control formulations. Formulations containing 3% PVP and 5% IPM produced the highest permeation rates (Jss, 85.35 µg/cm²/h).

Conclusion: These results indicate that incorporation of antinucleant polymer and permeation enhancers in aerosols containing ketoprofen enhances aerosol stability and drug permeation through rat skin.

Keywords: Ketoprofen, Antinucleant, Permeation enhancer, Topical aerosol, Transdermal delivery