Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Prevention of stress-related mucosal damage using intravenous omeprazole

Tiefeng Sun¹, Qing Xiao¹, ChaoFeng Gu², Xiaomin Diao³

¹Department of Emergency Medicine, the Eighth People's Hospital of Qingdao, Qingdao 266000, China; ²Department of Critical Care Medicine, Affiliated Qingdao Central Hospital of Qingdao University, Qingdao Cancer Hospital 266100, China; ³Department of Traditional Chinese Medicine, Qingdao Municipal Hospital, Qingdao 266001, China.

For correspondence:- Xiaomin Diao Email: diaoxiaomin123@outlook.com Tel:+8613280875023

Accepted: 23 February 2024 Published: 31 March 2024

Citation: Sun T, Xiao Q, Gu C, Diao X. Prevention of stress-related mucosal damage using intravenous omeprazole. Trop J Pharm Res 2024; 23(3):611-616 doi: 10.4314/tjpr.v23i3.16

© 2024 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To evaluate the effect of using intravenous injection of omeprazole to prevent stress-related mucosal damage (SRMD) in critically ill patients.

Methods: 80 critically ill patients from the Eighth People's Hospital of Qingdao, Qingdao, China were recruited and randomly divided into control and study groups comprising 40 patients each. Control group received conventional symptomatic treatment comprising nutritional support, acid-base balance regulation, electrolyte level monitoring and correction, maintenance of fluid and electrolyte equilibrium, respiratory function management, and anti-infection measures. Study group received intravenous injection of omeprazole (20 mg/day) and conventional symptomatic treatment for 3 months. Treatment effect, gastric pH, and gastroscopic observation of the two groups of patients were recorded.

Results: The study group demonstrated significantly higher treatment efficacy (97.5 %) compared to control group (80 %, p < 0.05). Pre-treatment gastric pH did not differ significantly between the groups (p > 0.05). After treatment, the study group exhibited significantly higher pH levels (p < 0.05). Normal endoscopic findings increased to 85 % in the study group compared to 20 % in control group (p < 0.05).

Conclusion: Intravenous omeprazole significantly prevents SRMD in critically ill patients, improves gastric pH regulation and reduces abnormal endoscopic findings. Larger-scale, multicenter, and long-term studies are needed to validate the findings of this study.

Keywords: Intravenous injection, Omeprazole, Prevention, Critically ill patients, Stress-related mucosal damage