Yu mei Wang1,
Chen ling Tang2,
Ming Che2 
,
Xiu qin Wang2,
Ai chen Li2
For correspondence:- Ming Che Email: go0654@163.com
Accepted: 29 August 2017 Published: 30 September 2017
Citation: Wang Ym, Tang Cl, Che M, Wang Xq, Li Ac. Prognostic value of vitamin D in patients with pneumonia: A systematic review and meta-analysis. Trop J Pharm Res 2017; 16(9):2267-2273 doi: 10.4314/tjpr.v16i9.31
© 2017 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To investigate the prognostic role of vitamin D in pneumonia patients through meta-analysis.
Methods: PubMed and Embase were systematically searched for relevant studies that assessed the impact of vitamin D on the risk of adverse outcomes among patients with pneumonia. Risk ratios (RR) with 95 % confidence intervals (95 % CI) were pooled using meta-analysis. Q-test and I2 statistics were used to evaluate between-study heterogeneity.
Results: Six studies were finally included in the meta-analysis. The results of meta-analysis of these studies indicated that low vitamin D status was associated with higher risk of mortality among pneumonia patients (RR = 2.59, 95 % CI = 1.32-5.08; p = 0.005). Results from meta-analysis of studies with adjusted estimates suggest that low vitamin D status was independently associated with higher risk of mortality among pneumonia patients (RR = 3.15, 95 % CI 1.54-6.44, p = 0.002). There was no significant risk of bias in the meta-analysis.
Conclusion: This study demonstrates that low vitamin D level is associated with a higher risk of adverse outcomes in patients with pneumonia.
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