Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Rice bran water extract attenuates pancreatic abnormalities in high-fat diet-induced obese rats

Wason Parklak¹ , Narongsuk Munkong², Surasawadee Somnuk¹, Nuntiya Somparn³, Jarinyaporn Naowaboot³, Bhornprom Yoysungnoen³, Nusiri Lerdvuthisopon³

¹Office of Graduate Studies, Faculty of Medicine, Thammasat University, Pathum Thani 12120; ²Department of Medicine, School of Medicine, University of Phayao, Phayao 56000; ³Department of Preclinical Science, Faculty of Medicine, Thammasat University, Pathum Thani 12120, Thailand.

For correspondence:- Wason Parklak Email: toon.wason@gmail.com Tel:+66942493687

Received: 17 November 2016 Accepted: 6 February 2017 Published: 30 April 2017

Citation: Parklak W, Munkong N, Somnuk S, Somparn N, Naowaboot J, Yoysungnoen B, et al. Rice bran water extract attenuates pancreatic abnormalities in high-fat diet-induced obese rats. Trop J Pharm Res 2017; 16(4):819-825 doi: 10.4314/tjpr.v16i4.11

© 2017 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To investigate the protective potential of rice bran water extract (RBE) from Khao Dawk Mali 105 on pancreatic abnormalities in high-fat diet (HFD)-induced obese rats.

Methods: Male Sprague-Dawley rats were divided into 4 groups: control group, HFD group, and HFD group treated with RBE at 2,205 or 4,410 mg/kg/day. After 4 weeks, body weight, glucose homeostatic parameters, and pancreatic fat accumulation were assessed. mRNA expression levels of sterol regulatory element-binding protein-1c (SREBP-1c), insulin receptor substrate-2 (IRS-2), glucose transporter-2 (GLUT-2) and glucokinase (GK) genes in pancreas were also analyzed.

Results: Compared with HFD group, two doses of RBE-treated rats significantly (p < 0.05) reversed HFD-induced obesity, hyperglycemia, impaired glucose tolerance and pancreatic triglyceride accumulation in rats. Histological examination of HFD-induced obese rats revealed fat droplets in acinar cells, but these alterations were ameliorated in RBE-treated rats. RBE treatment showed significantly (p < 0.05) decreased SREBP-1c expression, and also significantly (p < 0.05) increased IRS-2, GLUT-2 and GK expressions in pancreas.

Conclusion: RBE consumption may attenuate pancreatic abnormalities by inhibiting fat accumulation, as well as enhancing insulin sensitivity and glucose sensing in the pancreas of HFD-induced obese rats

Keywords: Rice bran, Obesity, Pancreatic steatosis, Insulin signaling, Glucose sensor