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Review Article | OPEN ACCESS

Role of endogenous peptides and enzymes in the pathogenesis of acute pancreatitis: A review

Bonam Srinivasa Reddy1,2, Sheba Dolly Bonigala1, Vijayapandi Pandy3

1Department of Pharmacology, Chalapathi Institute of Pharmaceutical Sciences, Guntur 522034, Andhra Pradesh; 2Vaccine Immunology Laboratory, Natural Product Chemistry Division, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500007, India; 3Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.

For correspondence:-  Vijayapandi Pandy   Email: pandiphd@gmail.com   Tel:+60379674712

Received: 7 February 2015        Accepted: 29 May 2015        Published: 29 July2015

Citation: Reddy BS, Bonigala SD, Pandy V. Role of endogenous peptides and enzymes in the pathogenesis of acute pancreatitis: A review. Trop J Pharm Res 2015; 14(7):1305-1310 doi: 10.4314/tjpr.v14i7.26

© 2015 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Acute pancreatitis is an inflammatory disease with the clinical manifestation of acute abdominal pain. Several factors are involved in the pathogenesis of acute pancreatitis. The exact mechanism(s) by which diverse etiological factors induce an attack are still unclear. However, one of the proposed mechanisms for induction of acute pancreatitis is auto-digestion of pancreatic tissues by unwanted activation of pancreatic digestive enzymes. The main objective of this review is to describe the pathogenesis mechanism of acute pancreatitis that are related to various inflammatory and pro-inflammatory mediators.

Keywords: Acute pancreatitis, Pancreatic injury, Cytokines, Chemokines, Inflammation

Impact Factor
Thompson Reuters (ISI): 0.6 (2023)
H-5 index (Google Scholar): 49 (2023)

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