Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Skin care benefits of bioactive compounds isolated from Zanthoxylum piperitum DC. (Rutaceae)

Sung Chun Kim, Mi Yeon Moon, Ha Youn Lee, Jungha Kim, Moon Sik Chang, Joonseok Cha

Research Center, The Garden of Naturalsolution Co Ltd, Osan-si, Gyeonggi-do, Republic of Korea;

For correspondence:- Joonseok Cha Email: jcha1@naturalsolution.co.kr

Accepted: 20 October 2019 Published: 30 November 2019

Citation: Kim SC, Moon MY, Lee HY, Kim J, Chang MS, Cha J. Skin care benefits of bioactive compounds isolated from Zanthoxylum piperitum DC. (Rutaceae). Trop J Pharm Res 2019; 18(11):2385-2390 doi: 10.4314/tjpr.v18i11.22

© 2019 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To investigate skin care efficacies of Zanthoxylum pipetitum extract and isolated compounds.

Methods: Ethanol extracts of leaves, branches and fruits of what were partitioned into n-hexane, chloroform, ethyl acetate, n-butanol and aqueous layers and some fractions were further analyzed to isolate five compounds. The isolated compounds were identified based on the proton and carbon nuclear magnetic resonance (NMR) spectra. Cosmetic efficacy tests of the extracts and isolated compounds were evaluated by in vitro tests.

Results: Phytochemical studies of the chloroform and ethyl acetate layers led to the isolation of five compounds; quercitrin (1), afzelin (2), hydroxy-α-sanshool (3), α-sanshool (4) and hyperoside (5). In activity tests, the extracts showed inhibitory activity against inflammation response and melanin synthesis, and induction of procollagen type I C-peptide (PIP). Among the isolated compounds, hydroxy-α-sanshool (3) and α-sanshool (4) displayed significant anti-inflammatory activity.

Conclusion: The results demonstrate that Z. piperitum extract and its active compounds possess a significant potential as a cosmeeutical agent for enhancing skin quality.

Keywords: Zanthoxylum piperitum, Quercitrin, Afzelin, Hydroxy-^5;-sanshool, ^5;-Sanshool, Hyperoside, Anti-inflammatory, Anti-aging