K G Singhal,
G D Gupta 
For correspondence:- G Gupta Email: drgdg@rediffmail.com
Received: 24 November 2010 Accepted: 4 June 2011 Published: 20 August 2011
Citation: Singhal KG, Gupta GD. Some Central Nervous System Activities of Nerium Oleander Linn (Kaner) Flower Extract. Trop J Pharm Res 2011; 10(4):455-461 doi: 10.4314/tjpr.v10i4.11
© 2011 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: The purpose of the study was to evaluate the activity of 50 % hydroalcohol flower extract of Nerium oleander Linn. on the central nervous system (CNS) of mice.
Methods: The effect of the 50 % hydroalcohol extract of N. oleander flowers at dosage levels of 100 and 200 mg/kg p.o. on the locomotor activity of mice was measured with an actophotometer while muscle relaxant activity was evaluated on rotarod apparatus. Also, the anticonvulsant activity of the extract in mice (following maximal electroshock and pentyleneterazol-induced convulsion) as well as the potentiation of pentobarbital-induced sleep were determined using standard procedures. Diazepam was used as the reference standard.
Result: The extract (at doses of 100 and 200 mg/kg) significantly reduced (p < 0.01) spontaneous locomotor activity and also potentiated pentobarbital-induced sleep. At the higher dose (200 mg/kg) the extract showed 66 % protection against electroshock-induced convulsions while the lower dose (100 mg/kg) produced a significant reduction (p < 0.01) in pentylenetetrazol (PTZ)-induced convulsions.
Conclusion: The ethanol extract of Nerium oleander flowers has anticonvulsant activity in an experimental animal model.
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