Tropical Journal of Pharmaceutical Research

Review Article | OPEN ACCESS

Targeting of protein expression in renal disease using siRNA – A review

Manal Ali Buabeid¹, Nihal Abdalla Ibrahim¹, Zelal Jaber Kharaba^2,3, Muhammad Ihtisham Umar⁴, Ghulam Murtaza⁴

¹Department of Clinical Sciences, College of Pharmacy and Health Sciences, Ajman University, Ajman 346; ²Department of Clinical Sciences, College of Pharmacy, Al Ain University of Science and Technology, Abu Dhabi, United Arab Emirates; ³Honorary Associate Lecturer, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, United Kingdom; ⁴Department of Pharmacy, COMSATS University Islamabad, Lahore Campus, Pakistan.

For correspondence:- Ghulam Murtaza Email: gmdogar356@gmail.com Tel:+923142082826

Accepted: 19 May 2020 Published: 30 June 2020

Citation: Buabeid MA, Ibrahim NA, Kharaba ZJ, Umar MI, Murtaza G. Targeting of protein expression in renal disease using siRNA – A review. Trop J Pharm Res 2020; 19(6):1313-1320 doi: 10.4314/tjpr.v19i6.28

© 2020 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

The kidneys have rarely been used as a target in the systemic delivery of siRNA when compared to other tissues or organs in the body. This review article deals with various modalities adopted to deliver siRNA to the renal system under different normal and pathophysiological states. In this article, the authors have reviewed extensive clinical data that describe the use of siRNA for the treatment of renal diseases. Conventional and 3D modeling utilizes the existing genome-based RNA libraries, which facilitated the identification of molecular pathways involved in renal diseases.

Keywords: siRNA, kidney disease, targeting proteins, signal pathways