Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

The Effect of Chemical and Physical Enhancers on Trolamine Salicylate Permeation through Rat Skin

Behzad Sharif Makhmal Zadeh , Mohammad Hossin Hasani

School of Pharmacy, Jundishapour University of Medical Sciences, Ahvaz, Iran;

For correspondence:- Behzad Makhmal Zadeh Email: bsharifmakhmalzadeh@yahoo.com Tel:+986113373747

Received: 13 February 2010 Accepted: 22 October 2010 Published: 23 December 2010

Citation: Makhmal Zadeh BS, Hasani MH. The Effect of Chemical and Physical Enhancers on Trolamine Salicylate Permeation through Rat Skin. Trop J Pharm Res 2010; 9(6):541-548 doi: 10.4314/tjpr.v9i6.4

© 2010 The authors.
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Abstract

Purpose: To achieve percutaneous delivery of trolamine salicylate to muscle and joints for the treatment of inflammatory muscle, tendon and joint diseases.

Methods: Trolamine salicylate permeability parameters through rat skin were evaluated with and without chemical enhancers - Transcutol, eucalyptus oil, oleic acid and sodium lauryl sulfate – using the permeability cell technique.

Results: The main barrier for trolamine salicylate permeability was the epidermis layer of the skin. Also, partitioning from the aqueous donor phase into the skin was the rate-limiting step for drug flux. Transcutol and eucalyptus oil were the most effective enhancers as they increased flux 11-fold. Sodium lauryl sulfate disrupted the lipid structure of the skin and thus increased diffusion coefficient 3-fold. Supersaturation technique did not increase flux. Propylene glycol in cosolvent system increased drug solubility in donor phase and partitioning.

Conclusion: Trolamine salicylate exhibited less flux and diffusion coefficient through rat skin than salicylic acid due to its hydrophilic property. Partitioning from vehicle into skin was the rate-limiting step for trolamine salicylate permeability through rat skin.

Keywords: Trolamine salicylate, Percutaneous absorption, Chemical enhancers, Supersaturation technique, Differential scanning calorimetry