Tropical Journal of Pharmaceutical Research

Review Article | OPEN ACCESS

Vitamin D associated inflammation and atherosclerosis

Seetha Munisamy, Sitisafiah Mokhtar, Low Jen Hou, Wee Chee Lee, Aida Hanum Ghulam Rasool

Pharmacology Vascular Laboratory, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kota Bharu, Malaysia;

For correspondence:- Aida Rasool Email: aida.rasool@yahoo.com Tel:+6097676123/6143

Accepted: 25 August 2018 Published: 30 July 2021

Citation: Munisamy S, Mokhtar S, Hou LJ, Lee WC, Rasool AH. Vitamin D associated inflammation and atherosclerosis. Trop J Pharm Res 2021; 20(7):1535-1547 doi: 10.4314/tjpr.v20i7.30

© 2021 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Vitamin D is known to play a crucial role in mineral homeostasis and bone metabolism. Recent discoveries showed that the vitamin also regulate the inflammatory mediators. A number of studies have reported on the association of low vitamin D levels with increased level of inflammatory parameters; which predisposes to atherosclerosis and development of cardiovascular diseases (CVD). Since inflammation is implicated in the pathogenesis of CVD, measurement of inflammatory marker levels has been proposed as a method to improve the prediction of these events. In this review, the mechanism of inflammation and role of vitamin D in combating inflammation are discussed

Keywords: cardiovascular disease, endothelial function, inflammation, high sensitivity C-reactive protein (hsCRP), vitamin D