Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Wound-healing effect of Platycodon grandiflorus (Jacq.) extract in rats

Liang Wang¹, Li Yang², Gang Yuan¹, Long-Jiao Hu³

¹Department of Pharmacy; ²Department of Orthopedics, Traditional Chinese Medicine Hospital of Jiulongpo District; ³Department of Pharmacy, Peopleâ€™s Hospital of Jiulongpo District, Chongqing 400050, China.

For correspondence:- Long-Jiao Hu Email: hulongjiao494@126.com Tel:+8618166572129

Accepted: 18 August 2019 Published: 30 September 2019

Citation: Wang L, Yang L, Yuan G, Hu L. Wound-healing effect of Platycodon grandiflorus (Jacq.) extract in rats. Trop J Pharm Res 2019; 18(9):1909-1912 doi: 10.4314/tjpr.v18i9.18

© 2019 The authors.
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Abstract

Purpose: To evaluate the healing effect of Platycodon grandiflorus (Jacq.). extract (PGE) on experimental burn wounds in rats.

Methods: Rats were randomly divided into four groups of eight rats each: control group, silver sulfadiazine (SSD)-treated group, moist exposed burn ointment (MEBO)-treated group and PGE-treated group. PGE, SSD and MEBO were applied topically twice daily for 7 days. SSD and MEBO were used as reference control. External observation of wound area contraction and histological analysis of wound tissues was performed respectively. The effect of PGE on matrix metalloproteases (MMPs), vascular endothelial growth factor (VEGF) and Type-III Collagen proteins of wound tissue in rats were analysed by Western blot.

Results: After 10 days of topical treatment with PGE, PGE-treated group showed faster reduction in wound area when compared with control groups (p < 0.01). Matrix metalloprotease-2 (MMP-2), matrix metalloprotease-9 (MMP-9), VEGF and type-III collagen expressions in the wound tissue increased significantly (p < 0.05) when compared with the control burn wounds. Histological results showed an overall early recovery and regeneration in PGE-treated group when compared with control group.

Conclusion: PGE possesses a significant wound-healing activity in full-thickness burn wounds in rats. Therefore, it can potentially be developed for the management of burns.

Keywords: Platycodon grandiflorus, Wound, Second-degree burns