Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Zhao Weitiao No 3 inhibits tumor growth in gastric cancer-bearing nude mice

Qi Pan^1,2, Pei Xiang², Yuanyuan Chen², Jingfang Zhao¹

¹Department of Oncology, Wuxi Affiliated Hospital of Nanjing University of Chinese Medicine, Wuxi, Jiangsu Province 210023, China; ²Department of Oncology, Wuxi No. 2 Chinese Medicine Hospital, Wuxi, Jiangsu Province 214071, China.

For correspondence:- Jingfang Zhao Email: jf_zhao0606@163.com Tel:+8651088859999

Accepted: 30 October 2022 Published: 30 November 2022

Citation: Pan Q, Xiang P, Chen Y, Zhao J. Zhao Weitiao No 3 inhibits tumor growth in gastric cancer-bearing nude mice. Trop J Pharm Res 2022; 21(11):2385-2389 doi: 10.4314/tjpr.v21i11.17

© 2022 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To investigate the effect of Zhao’s Weitiao No. 3 (ZW3) on the progression of gastric cancer (GC) in mice, and to determine its effects on the proliferation and apoptosis of gastric cancer tissues.

Methods: Tumor growth in vivo was used to determine the effect of ZW3 (15, 30, and 60 mg/kg) on GC growth in mice. Immunohistochemical and terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling assays were conducted to evaluate the effects of ZW3 on the proliferation and apoptosis of mouse GC tissues, while quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and immunoblot assays were conducted to determine its effects on GC cell apoptosis.

Results: ZW3 inhibited tumor growth in tumor-bearing mice, suppressed the expression of proliferation-related proteins (p < 0.001), increased the apoptosis of tumor cells in tumor-bearing mice (p < 0.001), and suppressed the expression of apoptosis-related proteins in mouse tumor tissues (p < 0.001).

Conclusion: Thus, ZW3 is a potential drug for the management of GC. However, further investigations are required to determine its full potential.

Keywords: Gastric cancer, Zhaoâ€™s Weitiao No. 3 (ZW3), Proliferation, Tumor growth, Apoptosis