Nimmathota Madhavi1 
,
Heera Battu2,
Madiki Manasa Angel3
For correspondence:- Nimmathota Madhavi Email: nimmathota.madhavi@gmail.com Tel:+91-9652631257
Received: 7 July 2024 Accepted: 14 January 2025 Published: 28 January 2025
Citation: Madhavi N, Battu H, Angel MM. Synergistic effect of Allium sativum and gliclazide on pharmacokinetic parameters in rabbit models. Trop J Pharm Res 2025; 24(1):47-52 doi: 10.4314/tjpr.v24i1.7
© 2025 The authors.
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Purpose: To assess gliclazide hypoglycemic effect in the presence of Allium sativum and determine the possible pharmacokinetics interactions of gliclazide and Allium sativa extract. Methods: A set of 6 Wistar rabbits weighing between 1.35 kg - 1.75 kg was used. Gliclazide (3.7 mg/kg) was administered orally. After a washout period of 1 week, the same group of animals received Allium sativum extract (56 mg/kg) with the required quantity of water. After a further washout period of 1 week, the same group received Allium sativum (56 mg/kg) 30 min prior to the administration of gliclazide (3.7 mg/kg). Blood samples were withdrawn at 0, 1, 2, 3, 4, 6, 8, 12, 16, 20 and 24 h and were analyzed for blood glucose using the glucose oxidase (GO)/peroxidase (PO) method. The mean significance of the pharmacokinetic parameters such as area under the curve (AUC)0–24, biological half-life (t1/2), maximum peak plasma concentration (Cmax), maximum time to reach Cmax (Tmax), and elimination rate constant (KE) of gliclazide was estimated with and without Allium sativum in rabbits. Results: Allium sativum significantly increased AUC0-24, AUC0-a and AUMC0-24 and Cmax of gliclazide (p < 0.05). The results revealed that Allium sativum significantly enhanced the hypoglycemic effect of gliclazide (p < 0.05). Conclusion: Allium sativum significantly enhances the hypoglycemic effect of gliclazide by improving pharmacokinetic parameters.
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