Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Prevalence and antibiotic susceptibility pattern of E. coli isolated from urinary tract infection in patients with renal failure disease and renal transplant recipients

Mohammad Aghazadeh¹, Soyar Sari², Mohammadreza Nahaie¹, Seyed Sadraddin Rasi Hashemi³, Samaneh Mehri¹

¹Department of Bacteriology and Virology, School of Medicine; ²Department of molecular and cellular science, Faculty of advanced sciences technology, Pharmaceutical sciences branch, Islamic Azad University, Tehran, Iran; ³Chronic Kidney Disease Research Center, Tabriz University of Medical Sciences, IR Iran.

For correspondence:- Samaneh Mehri Email: mehri.samaneh@gmail.com Tel:+982144652354

Received: 11 January 2015 Accepted: 22 March 2015 Published: 26 April 2015

Citation: Aghazadeh M, Sari S, Nahaie M, Hashemi SS, Mehri S. Prevalence and antibiotic susceptibility pattern of E. coli isolated from urinary tract infection in patients with renal failure disease and renal transplant recipients. Trop J Pharm Res 2015; 14(4):649-653 doi: 10.4314/tjpr.v14i4.13

© 2015 The authors.
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Abstract

Purpose: To determine the common uropathogens found in patients with urinary tract infections and to assess their antibiotic susceptibility patterns.

Methods: The prevalence and antibiotic susceptibility pattern of E. coli in urinary tract infection in-patients with renal failure disease and renal transplant recipients (group 1) and in outpatients (group 2), admitted in/attending Imam Reza Hospital in Tabriz, Iran, were determined. Isolates were analyzed by standard methods, and antimicrobial susceptibility testing was performed by Kirby-Bauer disc diffusion method.

Results: A total of 136 E. coli strains from 81 females and 55 males were examined. The high level of antibiotic susceptibility for group 1 was cefuroxime/ceftazidime (100 %) and nitrofurantoin (81.63 %), respectively; and for group 2, it was ampicillin (95.83 %) and nitrofurantoin (93.75 %), respectively.

Conclusion: The most important finding of this study is that a considerable proportion of the studied E. coli isolates are resistant to the antibiotics tested, except nitrofurantoin. This finding is useful for clinicians to determine appropriate empirical antimicrobial treatment in similar cases and would also help health authorities to formulate antibiotic prescription policies.

Keywords: Urinary tract infection, Antibiotic susceptibility pattern, Uropathogens, Renal failure, Renal transplant, Escherichia coli