Emdad Hossain1,
Subhash C Mandal2,
J K Gupta2 
For correspondence:- J Gupta Email: jkgjupt@yahoo.co.in Tel:+913324053055
Received: 8 August 2010 Accepted: 11 January 2011 Published: 14 February 2011
Citation: Hossain E, Mandal SC, Gupta JK. Phytochemical Screening and In-vivo Antipyretic Activity of the Methanol Leaf-Extract of Bombax Malabaricum DC (Bombacaceae). Trop J Pharm Res 2011; 10(1):55-60 doi: 10.4314/tjpr.v10i1.9
© 2011 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To investigate the antipyretic activity of the methanol extract of Bombax malabaricum leaves (MEBM) in rats.
Methods: Baker’s yeast was used to induce fever in Wistar rats which were divided into four groups. The animal groups were thereafter administered MEBM (200 mg/kg), MEBM (400 mg/kg), paracetamol (reference standard, 150 mg/kg) and 1 % Tween 80 (control), respectively. The body temperature of the rats was measured rectally over a period of 8 h. MEBM was also phytochemically screened for alkaloids, steroids, carbohydrates, tannins, fixed oils, proteins, triterpenoids, deoxy-sugar, flavonoid, cyanogenetic and coumarin glycosides.
Results: MEBM (200 mg/kg and 400 mg/kg) significantly reduced yeast-induced pyrexia (p < 0.05, p < 0.01, respectively). Phytochemical tests showed the presence of steroids, carbohydrates, tannins, triterpenoids, deoxy-sugars, flavonoids and coumarin glycosides.
Conclusion: The methanol extract of Bombax malabaricum leaves possesses significant antipyretic activity.
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