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Original Research Article | OPEN ACCESS

Formulation design and in vitro evaluation of berberine-loaded self-nanoemulsifying drug delivery system

Zhongcheng Ke , Zhi-Ping Zhu, Zhi-Yuan Xu, Chao Fang, Shang-Qing Hu

College of Chemistry and Chemical Engineering, Huangshan University, Huangshan, 245041, China;

For correspondence:-  Zhongcheng Ke   Email: xiaoke1020@126.com   Tel:+865592546612

Received: 19 December 2014        Accepted: 16 April 2015        Published: 26 May 2015

Citation: Ke Z, Zhu Z, Xu Z, Fang C, Hu S. Formulation design and in vitro evaluation of berberine-loaded self-nanoemulsifying drug delivery system. Trop J Pharm Res 2015; 14(5):747-752 doi: 10.4314/tjpr.v14i5.1

© 2015 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To improve the oral bioavailability of berberine using a new self-nanoemulsifying drug delivery system (SNEDDS).
Methods: Berberine SNEDDS was designed using solubility studies and phase diagram construction. A series of tests were carried out to study the effect of oil content, dilution, and drug loading on particle size. The morphology of the nanoemulsion was examined with a transmission electron microscope. Subsequently, the optimized berberine SNEDDS was investigated for in vitro release and compared with two marketed products (Xiaowei capsules and Beike tablets)
Results: The optimized formulation, composed of berberine of 6.0 %, castor oil of 18.8 %, Tween 20 of 37.6 %, and glycerol of 37.6 %, gave a mean particle size of approximately 60 nm, and was not affected by dilution. The optimized formulation released 90 % berberine in 20 min, while the reference products, Xiaowei capsules and Beike tablets, required 2 h to release 90 % of berberine.
Conclusion: The optimized formulation of SNEDDS is a potential alternative oral dosage form for improving oral absorption of berberine.

Keywords: Berberine, Pseudoternary phase diagram, Self-nanoemulsifying, SNEDDS, Drug release

Impact Factor
Thompson Reuters (ISI): 0.6 (2023)
H-5 index (Google Scholar): 49 (2023)

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