Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Effect of Elaeagnus Conferta Roxb (Elaeagnaceae) Dry Fruit on the Activities of Hepatic Alcohol Dehydro-genase and Aldehyde Dehydrogenase in Mice

Chongming Wu¹, Rongji Dai^1,2, Jingmiao Bai¹, Yan Chen^1,2, Yuhong Yu^1,2, Weiwei Meng^1,2 , Yulin Deng^1,2

¹School of Life Science, Beijing Institute of Technology, Beijing 100081; ²GY Pharmaceutical R&D, Beijing 100081, PR China.

For correspondence:- Weiwei Meng Email: mww919@bit.edu.cn Tel:+861068949331

Received: 18 March 2011 Accepted: 20 October, 2011 Published: 25 December 2011

Citation: Wu C, Dai R, Bai J, Chen Y, Yu Y, Meng W, et al. Effect of Elaeagnus Conferta Roxb (Elaeagnaceae) Dry Fruit on the Activities of Hepatic Alcohol Dehydro-genase and Aldehyde Dehydrogenase in Mice. Trop J Pharm Res 2011; 10(6):761-766 doi: 10.4314/tjpr.v10i6.9

© 2011 The authors.
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Abstract

Purposes: To determine the effect of Elaeagnus conferta Roxb dry fruit powder (ECR) on blood alcohol clearance and on the activities of hepatic alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH).

Methods: In a randomized controlled study, acute alcohol intoxication was induced in mice with Hongxing liquor containing 65 % v/v ethanol orally. The effect of ECR on blood alcohol clearance and on the activities of hepatic alcohol dehydrogenase and aldehyde dehydrogenase in the mice was then investigated.

Results: A 30-min pretreatment with ECR at 400 and 800 mg/kg led to a faster clearance of blood alcohol after the alcohol ingestion. The concentration of blood alcohol at 4 h after alcohol ingestion decreased by 21.2 % in mice pretreated with 800 mg/kg ECR. The activities of hepatic alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) were enhanced by ECR.

Conclusion: These results suggest that pretreatment with ECR might stimulate the clearance of blood alcohol by increasing the activities of hepatic alcohol dehydrogenase and aldehyde dehydrogenase.

Keywords: Elaeagnus conferta Roxb, blood alcohol clearance, alcohol dehydrogenase (ADH), aldehyde dehydrogenase (ALDH)