Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Preparation of Mucoadhesive Patches for Buccal Administration of Metoprolol Succinate: In Vitro and In Vivo Drug Release and Bioadhesion

Navneet Verma^1,2 , Pronobesh Chattopadhyay³

¹College of Pharmacy, IFTM University, Moradabad-244001 (U.P.); ²Institute of Pharmacy, Bhagwant University, Ajmer-305004 (Raj.); ³Defence Research Laboratory, Tejpur-784001 (Assam), India.

For correspondence:- Navneet Verma Email: navneet28jan@yahoo.com Tel:+919917731198

Received: 15 May 2011 Accepted: 14 December 2011 Published: 21 February 2012

Citation: Verma N, Chattopadhyay P. Preparation of Mucoadhesive Patches for Buccal Administration of Metoprolol Succinate: In Vitro and In Vivo Drug Release and Bioadhesion. Trop J Pharm Res 2012; 11(1):9-17 doi: 10.4314/tjpr.v11i1.2

© 2012 The authors.
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Abstract

Purpose: To develop mucoadhesive patches for buccal administration of metoprolol succinate and to evaluate their in vitro and in vivo bioadhesion.

Methods: The mucoadhesive buccal patches were prepared by solvent casting technique using two different mucoadhesive polymers. The formulations were tested for in vitro drug permeation studies, buccal absorption, in vitro drug release studies, moisture absorption as well as for in vitro and in vivo bioadhesion.

Results: The peak detachment force and work of adhesion for MC5 (sodium carboxymethylcellulose, i.e., Na CMC) patch were 0.87 N and 0.451 mJ respectively and the corresponding values for CH5 (chitosan) were 5.15N and 0.987 mJ. Formulation CH5 (prepared with chitosan) showed 67.1 % release, while MC5 (Na CMC) showed drug release of 81.9 % in 6 h. Basic pharmacokinetic parameters such as C_max, T_max and AUC_total varied statistically (p < 0.05) when given by the buccal route compared with that of the solution given by the oral route.

Conclusion: The results indicate that formulation of suitable bioadhesive buccal patches with the desired permeability is feasible. The development of bioadhesive buccal formulation for metoprolol succinate with a lower dose and few side effects may be attainable.

Keywords: Mucoadhesive, Buccal patches, Metoprolol succinate, Sodium carboxymethylcellulose, Chitosan, Bioavailability