Tropical Journal of Pharmaceutical Research

Review Article | OPEN ACCESS

Poly(ethylene oxide)-Poly(propylene oxide)-Based Copolymers for Transdermal Drug Delivery: An Overview

Evren Algin Yapar¹ , Özge İnal²

¹Ministry of Health of Turkey, Turkish Medicines and Medical Devices Agency, SÃ¶ğÃ¼tÃ¶zÃ¼ Mah. 2176. Sok. No:5 Kat:6, 06520 Ã‡ankaya-Ankara; ²Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Ankara, 06100 Tandoğan- Ankara, Turkey.

For correspondence:- Evren Yapar Email: algin@pharmacy.ankara.edu.tr Tel:+905323825686

Received: 30 January 2012 Accepted: 6 August 2012 Published: 18 October 2012

Citation: Yapar EA, İnal &. Poly(ethylene oxide)-Poly(propylene oxide)-Based Copolymers for Transdermal Drug Delivery: An Overview. Trop J Pharm Res 2012; 11(5):855-866 doi: 10.4314/tjpr.v11i5.20

© 2012 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Amphiphilic poly(ethylene oxide)–poly(propylene oxide) (PEO–PPO)-based copolymers are thermoresponsive materials having aggregation properties in aqueous medium. As hydrosolubilizers of poorly water-soluble drugs and improved stability of sensitive agents, these materials have been investigated for improvement in solubility, stability, release and bioavailability of drugs. The goal of the present review is to summarize the properties of PEO–PPO based copolymers and highlight the works that have been carried out on these materials for transdermal drug delivery.

Keywords: PEO-PPO based copolymer, Poloxamer, Hydrogel, Transdermal, Drug delivery