Sunny A Osagie1,
Ighodaro Igbe2 
,
Joseph E Osemwenkhae1
For correspondence:- Ighodaro Igbe Email: igbe.ighodaro@uniben.edu Tel:+2348166058559
Received: 7 November 2011 Accepted: 13 October 2012 Published: 13 December 2012
Citation: Osagie SA, Igbe I, Osemwenkhae JE. Comparison of Weibull and Probit Analysis in Toxicity Testing of Hunteria umbellata K Schum (Apocynaceae) Extract in Mice. Trop J Pharm Res 2012; 11(6):933-938 doi: 10.4314/tjpr.v11i6.9
© 2012 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose; Hunteria umbellata has been found to have therapeutic potentials in the treatments of diseases such as yaws, peptic ulcers, diabetes, piles and infertility in Nigeria; hence, the statistical analysis on the determination of acute toxicity of Hunteria umbellata was carried out in mice.
Methods; Data on the acute toxicity studies of the seed extract of Hunteria umbellata administered via the intraperitoneal route was analyzed using the two-parameter Weibull model.
Results; The median lethal dose (LD50) was 1.61 g/kg of body weight. This result falls in the neighbourhood of the median lethal dose earlier obtained in previous reports.
Conclusion; The results show that Hunteria umbellata may be slightly toxic when administered intraperitoneally.
Archives
News Updates
Fulltext in PDF