Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Antidiabetic, Antihyperlipidemic and Antioxidant Activities of Buchanania lanzan Spreng Methanol Leaf Extract in Streptozotocin-Induced Types I and II Diabetic Rats

N Sushma¹, Venkata P Smitha², Venu Y Gopal¹, R Vinay¹, Srinivasa N Reddy¹, Murali Ch Mohan², Butchi A Raju¹

¹St. Peterâ€™s Institute of Pharmaceutical Sciences, Warangal-506001; ²Department of Biotechnology, Gitam Institute of Technology, Gitam University, Visakhapatnam, 530045, India.

For correspondence:- Butchi Raju Email: drraju2020@gmail.com

Received: 17 July 2012 Accepted: 19 February 2013 Published: 24 April 2013

Citation: Sushma N, Smitha VP, Gopal VY, Vinay R, Reddy SN, Mohan MC, et al. Antidiabetic, Antihyperlipidemic and Antioxidant Activities of Buchanania lanzan Spreng Methanol Leaf Extract in Streptozotocin-Induced Types I and II Diabetic Rats. Trop J Pharm Res 2013; 12(2):221-226 doi: 10.4314/tjpr.v12i2.14

© 2013 The authors.
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Abstract

Purpose: To evaluate the antidiabetic, antihyperlipidemic and antioxidant activities of Buchanania lanzan.

Methods: Wistar rats were divided into nine groups of six animals each, and 40 mg/kg of streptozotocin or streptozotocin + nicotinamide was administered intraperitonially to induce types I and II diabetes. Those with blood glucose levels > 190 ± 8 mg/dl were administered the methanol leaf extract of Buchanania lanzan (MEBL, 100 or 200 mg/kg, p.o.) or positive control for 21 days. Blood glucose, lipid profile, antioxidant enzymes and oxidative stress markers were evaluated.

Results: Following induction, blood glucose level rose to 327.7 ± 47.4 mg/dl, compared to the normal value of 910 ± 3.2 mg/dl. Administration of MEBL (100 or 200 mg/kg) significantly (p < 0.05) decreased blood glucose level, serum lipid profile, and significantly (p < 0.05) increased antioxidant activity as evidenced by increase in super oxide dismutase (SOD), catalase, glutathione (GSH), and decrease in the activity of lipid peroxidation (LPO).

Conclusion: MEBL exhibits antidiabetic, antihyperlipidemic and antioxidant activities in diabetic rat and needs to be further investigated for the treatment of both types I and II diabetes mellitus.

Keywords: Antidiabetic, Antihyperlipidemic, Antioxidant, Buchanania lanzan