Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

In Vitro and In Vivo Evaluation of Diclofenac Sodium Gel Prepared with Cellulose Ether and Carbopol 934P

Dheeraj T Baviskar¹ , Yogeshkumar A Biranwar¹, Kapil R Bare¹, Venkatesh B Parik¹, Mangesh K Sapate¹, Dinesh K Jain²

¹Department of Pharmaceutics, Institute of Pharmaceutical Education, Boradi, 425 428, Tal-Shirpur, (M.S.); ²Department of Pharmaceutics, College of Pharmacy, IPS Academy, Indore, 452 012 (M.P.), India.

For correspondence:- Dheeraj Baviskar Email: baviskar@sancharnet.in Tel:+919850001942

Received: 14 July 2012 Accepted: 12 June 2013 Published: 23 August 2013

Citation: Baviskar DT, Biranwar YA, Bare KR, Parik VB, Sapate MK, Jain DK. In Vitro and In Vivo Evaluation of Diclofenac Sodium Gel Prepared with Cellulose Ether and Carbopol 934P. Trop J Pharm Res 2013; 12(4):489-494 doi: 10.4314/tjpr.v12i4.7

© 2013 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To develop diclofenac sodium gel using high molecular weight hydroxypropyl methylcellulose (HPMC) and Carbopol 934P for topical and systemic delivery.

Methods: Diclofenac sodium gel was prepared with HPMC K100M and Carbopol 934P as gelling agents. The formulations were examined for pH, spreadability, consistency, viscosity, homogeneity, drug content and stability. In vitro drug release was evaluated using Franz diffusion cell. Carrageenan-induced rat paw oedema model was used for the evaluation of the anti-inflammatory activity of the gels. A commercial diclofenac sodium gel product was used as the reference drug.

Results: Formulations containing glycerin as permeation enhancer gave drug release patterns comparable to that of the reference product. The drug content of F₂, F₅ and F₉ was 99.81, 99.75 and 99.96 %, respectively. Accelerated stability results showed no significant variation in the appearance and drug release after storage for 3 months.

Conclusion: Diclofenac sodium gel containing HPMC K100M and Carbopol 934P exhibited pronounced anti-inflammatory activity and could be further developed for topical and systemic delivery.

Keywords: Diclofenac sodium, Anti-inflammatory, Hydroxypropyl methylcellulose, Carbopol, Drug release, Glycerin