M S Akhtar1,
A Malik1,
M S Saleem1,
G Murtaza2 
1Faculty of Pharmacy, University of Sargodha, Sargodha;
2Department of Pharmaceutical Sciences, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan.
For correspondence:- G Murtaza
Email: gmdogar356@gmail.com Tel:+923142082826
Received: 17 July 2012
Accepted: 26 June 2013
Published: 23 August 2013
Citation:
Akhtar MS, Malik A, Saleem MS, Murtaza G.
Comparative Analgesic and Anti-inflammatory Activities of Two Polyherbal Tablet Formulations (Aujaie and Surangeen) in Rats. Trop J Pharm Res 2013; 12(4):603-607
doi:
10.4314/tjpr.v12i4.24
© 2013 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Abstract
Purpose: To investigate the analgesic and anti-inflammatory activities of two herbal polymedicines - Aujaie and Surangeen to ascertain their therapeutic claims.
Methods: A total of 96 rats were divided into two equal groups; one for determination of anti-inflammatory activity and the other for analgesic activity. Anti-inflammatory and analgesic activities were evaluated by carrageenan-induced paw edema and formalin-induced paw licking test, respectively. For both studies, group I (untreated control) received 1 ml/kg, (po) of gum suspension 1 h before carrageenan injection. Aspirin (100 mg/kg, po) was given to group II (treated control) before injection. Groups III, IV and V were administered orally aujaie (3, 4 and 5 mg/kg, po, respectively), while surangeen tablets (10, 20 and 40 mg/kg, po) were given to groups VI, VII and VIII, respectively. Pain was experimentally induced by injecting 0.1 ml of 2.5 % formalin (40 % formaldehyde in distilled water) via the subplantar region of the left hind paw.
Results: Significant (p < 0.05) anti-inflammatory activity for aspirin (group II as well as for groups III - VIII with paw edema inhibition (PDI) ranging from 24.6 - 90.2 %, There was significant ((p < 0.05) analgesic activity in group II, VI and VII while in groups III - V and VIII the activity was insignificant (p < 0.05).
Conclusion: Aujaie and surangeen tablets exhibited pronounced analgesic and anti-inflammatory activities in rats depending on the dose employed.
Keywords: Aujaie, Surangeen, Anti-inflammatory, Analgesic
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