Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Investigation of Association between Slime Production by Candida Spp and Susceptibility to Fluconazole and Voriconazole

Banu Kaskatepe , Sulhiye Yildiz

Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Microbiology, Ankara, Turkey;

For correspondence:- Banu Kaskatepe Email: bkaskatepe@ankara.edu.tr Tel:+90312 2033188

Received: 17 November 2012 Accepted: 4 June 2013 Published: 18 October 2013

Citation: Kaskatepe B, Yildiz S. Investigation of Association between Slime Production by Candida Spp and Susceptibility to Fluconazole and Voriconazole. Trop J Pharm Res 2013; 12(5):821-825 doi: 10.4314/tjpr.v12i5.24

© 2013 The authors.
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Abstract

Purpose: To determine the susceptibilities of fluconazole and voriconazole based on slime production by Candida spp.

Methods: Candida strains (115) isolated in the period between January 2011 and January 2012 were included in this study. Conventional methods were used for the identification. Candida albicans and non-C. albicans isolates were tested for slime production with modified tube adherence test and antifungal resistance with disk diffusion method.

Results: Slime positivity was 31.3 % in all Candida species. Slime positivity in non-C.albicans isolates (44.89 %) was higher than in C. albicans species (21.21 %). All C. albicans isolates were sensitive to fluconazole and voriconazole. The highest resistance to fluconazole (40 %) and voriconazole (5%) was by C. glabrata strains.

Conclusion: Species definition and determination of antifungal susceptibility patterns are advised for the proper management and treatment of patients.

Keywords: Candida, Fluconazole, Voriconazole, Antifungal susceptibility, Slime