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Original Research Article | OPEN ACCESS

Tyrosinase Inhibitory Activity and Thermostability of the Flavonoid Complex from Sophora japonica L (Fabaceae)

Jeng-Shiow Lai1,2, Chih-Chien Lin1 , Tsung-Ming Chiang3

1Department of Cosmetic Science, Providence University, No. 200, Sec. 7, Taiwan Boulevard, Shalu, Taichung City, 43301; 2Department of Beauty Science, Chienkuo Technology University, No. 1 Chiehshou North Road, Changhua City 500; 3Panion & BF Biotech Inc., 16 F, No. 3, Yuan. Chiu St., Nan Gang Dist., Taipei 115, Taiwan, ROC.

For correspondence:-  Chih-Chien Lin   Email: chchlin@pu.edu.tw   Tel:+886426328001

Received: 8 December 2012        Accepted: 31 December 2013        Published: 20 February 2014

Citation: Lai J, Lin C, Chiang T. Tyrosinase Inhibitory Activity and Thermostability of the Flavonoid Complex from Sophora japonica L (Fabaceae). Trop J Pharm Res 2014; 13(2):243-247 doi: 10.4314/tjpr.v13i2.12

© 2014 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To investigate the tyrosinase inhibitory activity and thermostability of weak acid-treated Sophora japonica L. flavonoid complex (SJ-FC) in different solutions.
Methods: The flavonoid complex of S. japonica was isolated and treated with weak acid to generate SJ-FC. The anti-tyrosinase activities of SJ-FC and well-known tyrosinase inhibitors were compared by mushroom tyrosinase activity assay. The thermostabilities of SJ-FC and other inhibitors in different solution environments for long-term storage were also investigated.
Results: The results indicate that SJ-FC has potent tyrosinase inhibitory activity, and at a concentration of 0.1 %, SJ-DC has a tyrosinase inhibitory activity equal to that of 1 % ascorbic acid or hydroquinone. In addition, SJ-FC in both propylene glycol (PG) and glycerol solutions exhibited obvious tyrosinase inhibitory activity. Ascorbic acid and arbutin, two other tyrosinase inhibitors, exhibit < 60 % of their initial activity in both PG and H2O solutions after 6 months of storage. However, SJ-FC stored in PG and H2O solutions retained almost 100 % of its activity over a 6-month period.
Conclusion: SJ-FC is an effective and stable anti-tyrosinase agent and may be used as a function agent in medicines, foods and cosmetics.

Keywords: Flavonoid, Sophora japonica L., Tyrosinase inhibitor, Thermostability

Impact Factor
Thompson Reuters (ISI): 0.6 (2023)
H-5 index (Google Scholar): 49 (2023)

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