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Original Research Article | OPEN ACCESS

Factors Associated with Treatment Response to Antidiabetic Agents in Compliant Type 2 Diabetes Mellitus Patients: A Brief Summary of 5-Year Data

Hasniza Zaman Huri1,2 , Lee Tze Xiang2

1Clinical Investigation Centre, Faculty of Medicine,13th Floor Main Tower, University Malaya Medical Centre, 59100 Lembah Pantai Kuala Lumpur; 2Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia.

For correspondence:-  Hasniza Huri   Email: hasnizazh@um.edu.my   Tel:+60379676657

Received: 6 March 2013        Accepted: 11 January 2014        Published: 24 March 2014

Citation: Huri HZ, Xiang LT. Factors Associated with Treatment Response to Antidiabetic Agents in Compliant Type 2 Diabetes Mellitus Patients: A Brief Summary of 5-Year Data. Trop J Pharm Res 2014; 13(3):429-435 doi: 10.4314/tjpr.v13i3.18

© 2014 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To evaluate the response to diabetic medications and factors influencing drug response in compliant type 2 diabetes mellitus (T2DM) patients.
Methods: A cross-sectional, retrospective study was performed on 100 T2DM patients at the University Malaya Medical Centre (UMMC) who were prescribed with at least one antidiabetic medication between January 2007 and December 2011.
Results: Using data from their medical records, it was determined that both fasting plasma glucose (FPG) and glycated hemoglobin (A1c) levels among all subjects were lower than baseline values. However, the reductions were not significant (p = 0.239 and p = 0.093). Factors that were significantly associated with the response to diabetic medications, include hypertension (p = 0.011), sulfonylureas (p = 0.041), beta-blockers (p = 0.005), and baseline A1c levels (p < 0.001).
Conclusion: Treatment of T2DM can be further optimized to ensure that diabetes is well-controlled.

Keywords: Treatment response; Antidiabetics; Type 2 Diabetes Mellitus, Hypertension, Beta-blocker

Impact Factor
Thompson Reuters (ISI): 0.6 (2023)
H-5 index (Google Scholar): 49 (2023)

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