Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Effects of Ganoderma lucidum spent mushroom substrate extract on milk and serum immunoglobulin levels and serum antioxidant capacity of dairy cows

Yanling Liu^1,2, Chao Zhao^2,3, Dongmei Lin¹, Haijuan Lan⁴, Zhanxi Lin^1,2

¹College of Life Science, Fujian Agriculture and Forestry University; ²National Engineering Research Center of Juncao, Fuzhou, Fujian 350002; ³College of Food Science; ⁴ChangFu Dairy of Fujian Co., Ltd, Nanping, Fujian 353000, China.

For correspondence:- Zhanxi Lin Email: lzxjuncao@163.com Tel:+8659183789223

Received: 12 December 2014 Accepted: 25 May 2015 Published: 29 June 2015

Citation: Liu Y, Zhao C, Lin D, Lan H, Lin Z. Effects of Ganoderma lucidum spent mushroom substrate extract on milk and serum immunoglobulin levels and serum antioxidant capacity of dairy cows. Trop J Pharm Res 2015; 14(6):1049-1055 doi: 10.4314/tjpr.v14i6.16

© 2015 The authors.
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Abstract

Purpose: To investigate the effects of Ganoderma lucidum hot water extract (HWE) from spent mushroom substrate on milk and serum immunoglobulin levels and serum antioxidant capacity.

Methods: Forty cows within the same parity and stage of lactation and with similar body weight were randomly divided into four groups of 10 cows each. The daily dietary dosage of HWE was 0, 33, 67, and 100 g for control and the three experimental groups EG1, EG2, and EG3, respectively. Serum antioxidant activity as well as milk and serum immunoglobulin levels were measured by enzyme-linked immunosorbent assay (ELISA).

Results: After administration for 60 days, no significant differences in milk IgG, IgA, or IgM concentrations were detected among the experimental groups, but serum IgA concentration was significantly higher in EG1, EG2, and EG3 groups compared with control group (p < 0.01). Additionally, significant differences were detected in serum total antioxidant capacity (TAC) and mean serum TAC concentration among control, EG1, EG2, and EG3 groups (p < 0.05).

Conclusion: The results suggest that when utilized as a feed additive, HWE may enhance immunity and antioxidant capacity in dairy cows, and subsequently improve milk quality.

Keywords: Ganoderma lucidum, Spent mushroom substrate, Immunoglobulin, Antioxidant capacity, Dairy cows