Sonia A Alonso - González1,
Leticia Garduño-Siciliano1,
Edgar Cano-Europa2,
María RE Ortiz-Butrón2,
Elizdath Martínez-Galero1 
,
María E Meléndez-Camargo1
For correspondence:- Elizdath Martínez-Galero Email: emartingal@gmail.com Tel:+525557296000
Received: 23 July 2013 Accepted: 29 March 2014 Published: 26 June 2014
Citation: Alonso - González SA, Garduño-Siciliano L, Cano-Europa E, Ortiz-Butrón MR, Martínez-Galero E, Meléndez-Camargo ME. Antioxidant and Hypoglycaemic Effects of Ardisia Compressa (HBEK, Myrsinaceae) Extract in Type 2 Diabetic Rats. Trop J Pharm Res 2014; 13(6):913-920 doi: 10.4314/tjpr.v13i6.13
© 2014 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To evaluate the possible hypoglycaemic, hypolipidemic, and antioxidant activities of Ardisia compressa (AC) on a rat model of type 2 diabetes.
Methods: Diabetes was induced in female Wistar rats by intraperitoneal (i.p.) administration of streptozotocin (65 mg/kg) and nicotinamide (120 mg/kg). The diabetic animals were orally administered water with or without metformin 150 mg/kg (D+Met) or 100, 200, or 400 mg/kg AC (D+100, 200 or 400), daily for 21 days. Normoglycaemic animals were given water with or without 400 mg/kg AC. Glycaemia, urinary protein excretion, lipid profiles, and antioxidant activity were determined.
Results: AC decreased hyperglycaemia in diabetic animals (150.67 ± 13.41 mg/dL, AC vs. 346.33 ± 51.21 mg/dL, Diabetes), but not hyperlipidemia. An antioxidant effect was also observed in the 400-mg/kg AC extract group, which exhibited significantly decreased lipid peroxidation (2.597 ± 0.284, AC vs. 3.623 ± 0.280 μM malondialdehyde [MDA]/g, Diabetes) and reactive oxygen species (ROS) production (1.533 ± 0.207, AC vs. 5.281 ± 0.457 μg DCF/mg, Diabetes) in liver. In addition, lipid peroxidation, ROS, and oxidised proteins levels were decreased in the kidneys and pancreas of AC treated diabetic animals.
Conclusion: AC leaves exert hypoglycaemic and antioxidant effects in type 2 diabetic rats, and has the potential to delay or prevent the onset of diabetes-induced complications.
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