Ayesha Rashid,
Mahmood Ahmad 
,
Ume Ruqia Tulain,
Furqan Muhammad Iqbal
For correspondence:- Mahmood Ahmad Email: ma786_786@yahoo.com Tel:011-92-062-9255565
Received: 25 February 2015 Accepted: 16 June 2015 Published: 29 July 2015
Citation: Rashid A, Ahmad M, Tulain UR, Iqbal FM. Fabrication and evaluation of 2-hydroxyethyl methacrylate-co-acrylic acid hydrogels for sustained nicorandil delivery. Trop J Pharm Res 2015; 14(7):1121-1128 doi: 10.4314/tjpr.v14i7.1
© 2015 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To fabricate and evaluate oral 2-hydroxyethyl methacrylate-co-acrylic acid hydrogels as a drug delivery system for sustained release of nicorandil.
Methods: HEMA-co-AA hydrogels using different monomer concentrations were prepared by free radical polymerization. N, N-methylene bis acrylamide (MBA) was used as crosslinker and potassium persulphate (KPS) as initiator. Nicorandil (20 mg) loaded hydrogels were characterized by Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis and differential scanning calorimetry (DSC) and scanning electron microscopy (SEM) . Swelling ratio, equilibrium swelling (ES), gel content (gc), porosity measurement (P) and in vitro drug release of the delivery system were evaluated.
Results: Swelling ratio and ES decreased as AA concentration (%) was reduced from 3.173 to 2.93 (pH 1.2) and 16.42 to 15.01 (pH 7.4) and 68.49 to 65.90 (pH 1.2) and 93.91 to 93.34 (pH 7.4), respectively, while HEMA and MBA showed opposite effects. Gel content (%) and porosity (%) ranged from 83.76 to 88.0, respectively from F1 to F9. With increase monomer content (AA), drug release increased from 85.99 to 89.38 %. However, when the concentrations of HEMA and MBA were raised, drug release decreased.
Conclusion: HEMA-co-AA hydrogels are potential pH-sensitive and sustained-release system for nicorandil.
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